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[MyJournals.org - RSS feed for news from the category 'All'] Effective knowledge management in translational medicine: Background:The growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences departments across pharma as well as academic and government supported initiatives such as Clinical and Translational Science Awards (CTSA) in the US and the Seventh Framework Programme (FP7) of EU with emphasis on translating research for human health.Methods:The pharmaceutical companies of Johnson and Johnson have established translational and biomarker departments and implemented an effective knowledge management framework including building a data warehouse and the associated data mining applications. The implemented resource is built from open source systems such as i2b2 and GenePattern.Results:The system has been deployed across multiple therapeutic areas within the pharmaceutical companies of Johnson and Johnsons and being used actively to integrate and mine internal and public data to support drug discovery and development decisions such as indication selection and trial design in a translational medicine setting.

[Journal of Translational Medicine - Latest Articles] Journal of Translational Medicine | Full text | Epigenetics of ...: 2, are found methylated with similar frequencies in primary and metastatic CM, suggesting their methylation as being an early event in CM, while others have higher frequencies in advanced disease (e.g., MGMT, RASSF1A, DAPK), suggesting the implication of their aberrant hypermethylation in CM progression [39]. Along this line, a recent paper by Tanemura et al reported the presence of a CpG island methylator phenotype (i.e., high incidence of concomitant methylation of different CpG islands) in CM, which was associated with advancing clinical tumor stage.

[Beta health] Ariadne to Collaborate in 7.5M Euro Neuromuscular Disease ...: Pathway Studio, built and powered by MedScan® technology, is integrated premises mining and visualization software that allows organizations and researchers to quickly extract relevant facts and relationships from large document collections (text-mining), build focused knowledgebases (databases), while supporting the integration of OMICS experiments.

[Journal of Translational Medicine - Latest Articles] Journal of Translational Medicine | Full text | An integrative ...: Novel platforms based on newly developed technologies are at the cusp of revolutionizing our ability to be comprehensive in correlative study design. Some examples of these exciting advances include the development of methodologies to couple antibodies to elemental isotopes combined with the use of inductively coupled plasma mass spectrometry (ICP-MS) to detect and quantify the antibodies in atomized and ionized samples [32], the conjugation of antibodies to single strand DNA oligomers (DEAL-DNA Encoded Antibody Libraries) that can bind to nucleic acids or proteins in biological samples and the use of microfluidics-based instrumentation to interrogate individual cell samples in a multiplex manner [33], and the development of emulsion PCR coupled with microfluidics to simultaneously perform and collect data on thousands of PCR reactions in parallel [34].

[SLA Biomedical & Life Sciences Division Blog] SLA Biomedical & Life Sciences Division Blog: Major Developments ...: Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries - Principal results from EUROASPIRE II Euro Heart Survey programme. European Heart Journal 22, (7) (APR): 554-72.

[NeuroLogica Blog] NeuroLogica Blog » Potential New Mechanism of Pain Relief Discovered: It’s origin in a completely different language creates significant translational issues. Perhaps the most significant is that a single word in Chinese frequently can be translated into multiple different concepts in English, only some of which can be clarified by contextual clues.

[TEXTBOOKS COLLECTION] TEXTBOOKS COLLECTION: Daftar Teksbook 8: Breast Cancer Genes and the Gendering of Knowledge;Sahra Gibbon (Author) -;Breast Cancer Management and Molecular Medicine;Martine J. Piccart, William C. Wood, Chie-Mien Hung, Lawrence J. Solin, Fatima Cardoso (Editors) ... Breast Cancer: Translational Therapeutic Strategies (Translational Medicine);Gary H. Lyman (Editor), Harold J. Burstein (Editor) -;Breast Diseases (Vademecum);Patrick I. Borgen Arnold D. K. Hill -;Breast Imaging, 3/e 2006;Daniel B Kopans ...

[CAMLAW: Complementary and Alternative Medicine Law Blog] Integrative medicine helping oncology patients : CAMLAW ...: The integrative oncology services are part of a larger 360 Care Program that recently launched aimed to address cancer patients' needs from every angle through treatment that extends beyond medical therapies, to include counseling, stress management and integrative medicine. Integrative oncology services include acupuncture, massage, energy healing and naturopathic medicine offered by Northwestern Memorial Physicians Group's Center for Integrative Medicine and Wellness.

[Clinical Research Associate (CRA) 工作日记] Establishing Singapore as Asia's Clinical Trials Hub_Clinical ...: These national efforts, together with the presence of world-class, research-oriented hospitals and specialty centres help to build up clinical trial expertise and capabilities in Singapore. The hospitals and institutes, such as the National University Hospital, Singapore General Hospital, Tan Tock Seng Hospital, National Cancer Centre, National Neuroscience Institute, National Heart Centre, Singapore Eye Research Institute and the Institute of Mental Health conduct their own medically and scientifically complex clinical trials.

[JulianCaroline] algiatry drugs: Translational Medicine • Imaging • Regulatory Affairs • Business Development • Licensing and External Research • Quality Control/Assurance • Global Marketing and Medicine. Day 1 7th Annual Pain Management Monday 18th October 2010 .

[Medical Query] iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular ...: iPierian is a South San Francisco-based biopharmaceutical company focused on the industrialization of induced pluripotent stem cell (iPS) technology with the mission of creating new therapeutics through cellular reprogramming and directed differentiation of patient cells. iPierian is backed by Kleiner Perkins Caufield & Byers, Highland Capital Partners, MPM Capital and FinTech Global Capital.

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